Authors and Affiliations: Rita Lima-Sousa a, Bruna L. Melo a, António G. Mendonça a,b, Ilídio J. Correia a,c, Duarte de Melo-Diogo a a CICS-UBI – Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal b Departamento de Química, Universidade da Beira Interior, 6201-001 Covilhã, Portugal c CIEPQPF – Departamento de…
Medical reports are a rich source of data, but their use in computer vision often requires additional annotations, marking points on images anew. This study examines the relationship between pulmonary nodules references in medical reports and their presence in CT scan images. It found that while radiologists tend to make more manual image annotations, this…
Spinal cord injury (SCI) is a severely traumatic condition that can have a devastating effect on the life of patients. It is estimated that over 130,000 people are affected by SCI each year, often resulting in significant neurological and functional impairments. Current treatments for SCI typically involve surgical interventions and pharmacological agents, but unfortunately, no…
Researchers from the Differentiation and Cancer group at i3S investigated the expression of the MISP protein and its clinical relevance in gastric cancer. The study, titled “MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer,” was recently published in the journal Current Oncology. Gastric cancer remains a major health problem worldwide, so the identification of…
Authors and affiliations:João Franco Machado,1 Sandra Cordeiro,2,3 Joana N. Duarte,1 Paulo J. Costa,4 Paulo J. Mendes,4,5 Maria Helena Garcia,1 Pedro V. Baptista,2 Alexandra R. Fernandes,2 and Tânia S. Morais1 1 Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal 2 Associate Laboratory i4HB – Institute…
Pathologists demonstrate that GATA3 may be expressed in metastatic adenocarcinoma of the prostate, constituting an important diagnostic pitfall. Authors and affiliationsJoão Lobo 1 2 3, Nazario P Tenace 4, Sofia Cañete-Portillo 5, Isa Carneiro 1 2, Rui Henrique 1 2 3, Roberta Lucianò 4, Lara R Harik 6, Cristina Magi-Galluzzi 5 1Department of Pathology, Portuguese…
Recent advancements in mouse models for studying exosomes have provided new insights into their roles in various biological contexts. Exosomes are tiny particles that cells release to communicate with each other. Using a new genetic mouse model, we tracked exosomes from pancreas cells and studied their behavior during pancreatic ductal adenocarcinoma, a type of pancreatic…
Researchers from the Cancer Biology & Epigenetics Group at the Research Center of IPO Porto, Portugal have revealed a pivotal link between epigenetic regulation and prostate cancer radioresistance. The study, entitled “Epigenetic Regulation of TP53 is Involved in Prostate Cancer Radioresistance and DNA Damage Response Signaling,” was recently published in the prestigious journal Signal Transduction…
Breast cancer is a heterogeneous disease, but 70% of cases are characterized by the presence of hormone receptors for estrogen, progesterone, or both. The first line of treatment for these patients, when presenting with metastatic disease, is endocrine therapy in combination with CDK4/6 inhibitors, but the majority develops resistance to treatment within two years. Now,…
Authors and Affiliations: José Garcia-Pelaez 1, Rita Barbosa-Matos 2, Silvana Lobo 2, Alexandre Dias 3, Luzia Garrido 4, Sérgio Castedo 5, Sónia Sousa 3, Hugo Pinheiro 6, Liliana Sousa 7, Rita Monteiro 8, Joaquin J Maqueda 9, Susana Fernandes 10, Fátima Carneiro 5, Nádia Pinto 11, Carolina Lemos 12, Carla Pinto 13, Manuel R Teixeira…