Authors and Affiliations: Pedro Rodrigues (1,3), Paulo Matos (1,2), João Gonçalves (1,3) and Peter Jordan (1,2) 1 Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge, 1649-016 Lisbon, Portugal; 2 BioISI – Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal; 3 Comprehensive Health Research Centre (CHRC,…
A team of researchers from the Institute for Research and Innovation in Health (i3S) at the University of Porto has identified persistent vulnerabilities in colorectal tumors that could be exploited to develop personalized therapeutic cancer vaccines. The study, published in the journal Gut, shows that although these tumors can evade immune surveillance, they retain neoantigens…
An international team of researchers led by Patricia Rijo (Lusófona University) has recently published a study demonstrating the anticancer potential of derivatives inspired by natural products. The investigated compounds, naphthyl derivatives based on flavonoid structures, were initially developed during the PhD research of Emília Leitão, currently a researcher at Hovione FarmaCiência. The recently published work…
Researchers from the Digital Surgery Lab at the Champalimaud Foundation have developed an automatic 3D surface scanning system that captures breast cancer patients’ anatomy in just one second. The study, involving 30 patients, demonstrated that the system is significantly faster and more user-friendly than current manual methods, paving the way for using “Digital Twins” to…
This study focuses on glioblastoma, a highly aggressive and deadly brain tumor characterized by a dismal 5-year survival rate of ~6% and the absence of effective treatments. This poor prognosis is largely due to tumor heterogeneity and the high rate of recurrence following conventional therapies. In this context, the researchers investigated the antitumoral potential of…
A study published in Anticancer Research identified genetic variants in SLC1A5, SLC7A5, and SLC3A2 associated with survival in colorectal cancer patients. These findings highlight the role of tumor genetics in prognostic stratification and personalized treatment approaches. Authors and Affiliations: Catarina Lopes (1,2,3), Catarina Macedo-Silva (4), Mónica Farinha (5), João Costa (5), Sofia Pinelas (6), Isabel…
Authors and Affiliations: Eduarda Ribeiro 1,2 and Nuno Vale 1,3,4,* 1 PerMed Research Group, RISE-Health, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal; [email protected] 2 School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal 3 RISE-Health, Department of Community Medicine,…
Pediatric brain tumors are the leading cause of cancer-related deaths in children. Although modern genetic technologies have greatly improved our understanding of these tumors, turning this knowledge into safer and more effective treatments remains difficult. One major challenge is the lack of laboratory models that truly reflect the complexity and diversity of childhood brain tumors….
This work recently published in the “International Journal of Cancer” demonstrated the possibility of repurposing pirfenidone (an antifibrotic drug) in combination with vinorelbine or with vinorelbine plus carboplatin for the perioperative treatment of non-small cell lung cancer (NSCLC), with the aim of improving therapeutic efficacy while reducing toxicity. This work resulted from a collaboration between…
Researchers from the Glycobiology in Cancer at i3S established a unique biobank of patient-derived gastric organoids showing that these models faithfully reproduce human tissue glycosylation across stages of gastric carcinogenesis. The study further demonstrates that organoids retain tumor heterogeneity and dynamically regulate Lewis antigens, shaping Helicobacter pylori interactions. Authors and Affiliations: Liliana Santos-Ferreira1,2,3, Álvaro M….