From left to right: Maria Graça Neves, Amparo Faustino, Mariana Mesquita e Margarida Fardilha. Authors and Affiliations: Mariana Q. Mesquita*^, Ana Rita Ferreira*, Maria da Graça P.M.S. Neves^, Daniela Ribeiro*, Margarida Fardilha*, Maria A.F. Faustino^ * Instituto de Biomedicina – iBiMED & Departamento de Ciências Médicas, Universidade de Aveiro, 3810-193 Aveiro, Portugal ^ Departmento de…
Authors and Affiliations: Ana Cláudia Pereira1,2,3,*, Débora Ferreira1,2,*, Cátia Santos-Pereira1,4,5, Tatiana F. Vieira4, Sérgio F. Sousa4, Goreti Sales3 and Lígia R. Rodrigues1,2 1 CEB – Centre of Biological Engineering, University of Minho, Braga, Portugal 2 MIT-Portugal Program, Lisbon, Portugal 3 Biomark – Sensor Research, Superior Institute of Engineering of Porto, Porto, Portugal 4 UCIBIO@REQUIMTE –…
The mechanical properties of cells and extracellular environment, in particular their stiffness and adhesion capacity, are important in the early stages of bladder cancer initiation. A computational model, developed at the University of Coimbra, describes the different layers of the urothelium and allows to study which characteristics are most relevant to the invasive capacity of…
A investigação e a inovação em cancro na América Latina são limitadas devido a recursos académicos inadequados e a investigação de translação depende quase totalmente de financiamento público. A complexidade regulatória e os prazos de resposta excessivos colocam colocam em causa a melhoria potencial na participação em estudos internacionais. Tecnologias emergentes, inteligência artificial, big data…
Over 70% of breast cancers (BC) are estrogen receptor-positive (ER+). The Notch ligand Delta-like 1 (DLL1) is a key player in ER+ BCs development and aggressiveness and its overexpression are associated with poor prognosis. In this study, Portuguese researchers developed a novel anti-DLL1 antibody that inhibited tumor growth and liver metastases in a xenograft mouse…
Cervical cancer (CC) is considered the 4th most common cause of death in women worldwide, with over 99% of cases related to human papilloma virus (HPV) infection. According to data from Globocan, in 2020, there were 341 831 deaths, with a higher incidence in developing countries, mainly due to limited financial resources and access to…
Authors and Affiliations: Inês Direito1, Liliana Monteiro1, Tânia Melo2, Daniela Figueira1, João Lobo3,4,5, Vera Enes1, Gabriela Moura1, Rui Henrique3,4,5, Manuel A. S. Santos1, Carmen Jerónimo3,4,5, Francisco Amado2, Margarida Fardilha1 e Luisa A. Helguero1 1 iBiMED—Institute of Biomedicine, Universidade de Aveiro, 3810-193 Aveiro, Portugal; 2 LaQV-REQUIMTE—Associated Laboratory for Green Chemistry of the Network of Chemistry and…
Ewing’s Sarcoma (ES) is the second most frequent bone tumour in children and young adults, with very aggressive behaviour and significant disease recurrence. To better study the disease and find new therapies, experimental models are needed. In this work, we developed a novel ES cell culture method based on 3D spheroids. Our culture method maintains…
Authors and Affiliations: Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia-da-Silva, Natércia Teixeira UCIBIO.REQUIMTE, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto Abstract: Breast cancer is currently the leading cause of cancer-related death in women worldwide. Despite the therapeutic efficacy of the current treatments used in clinic, most of the drugs cause…
Cumprindo o seu objetivo de promover a investigação em cancro em Portugal, nomeadamente através da recolha de indicadores e disseminação de resultados, bem como da análise e proposta de soluções para os constrangimentos existentes na investigação nacional em Oncologia, a ASPIC, com o apoio da Fundação “la Caixa”, Fundação Calouste Gulbenkian e Novartis, promoveu a…