Authors and affiliations:Joana FS Pereira, Cláudia Bessa, Paulo Matos and Peter Jordan Instituto Nacional de Saúde Doutor Ricardo Jorge, BioISI- Biosystems & Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa Abstract:An inflammatory microenvironment is a tumour-promoting condition that provides survival signals to which cancer cells respond with gene expression changes. One example is…
Authors and Affiliations: Carolina F Ruivo # 1 2 3, Nuno Bastos # 1 2 3, Barbara Adem 1 2 3, Ines Batista 1 2 3, Cecilia Duraes 1 2, Carlos A Melo 4, Stephanie A Castaldo 1 5, Francisco Campos-Laborie 4, Pedro Moutinho-Ribeiro 6 7, Barbara Morão 8, Ana Costa-Pinto 1 2, Soraia Silva…
The health of the population is crucial for the development of society. Unfortunately, current health systems are under increasing pressure, greatly aggravated by the Covid-19 pandemic, which, consequently, has made the work of health professionals in the field of oncology difficult. Cancer is the second leading cause of death worldwide and it is estimated that…
Authors and Affiliations: Flávia Pereira 1,2,3,4, Anabela Ferreira 1,2, Celso Albuquerque Reis 3,5,6, Maria João Sousa 1,2, Maria José Oliveira 3,4,5 and Ana Preto 1,2 1 Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal 2 Institute of Science and Innovation for Bio-Sustainability (IB-S), Campus…
Since 2018, the Barretos Cancer Hospital, Barretos, SP, Brazil, has carried out molecular tests to subclassify a brain tumor called medulloblastoma that occurs most often in children, but can also occur in adults. This classification is important to direct more appropriate treatments. The method used to classify pediatric brain tumors involves the use of a…
Helicobacter pylori is one of the most successful human pathogens worldwide. This bacterium infects the stomach of nearly half of the world’s population and is directly responsible for 90% of all diagnosed gastric cancers, the fifth most common and the fourth deadliest. One would think that in the 21st century, this infection would be cleared…
The new focus-locking technique involves growing cell on glass coverslips with specially 3D-printed nanometre particles called ‘fiducials’, which act as markers to stabilise or ‘lock’ the microscope as it is recorded. Being able to control the 3D-architecture and positioning of the guide markers at the nanoscale means that microscopists have greater control of the imaging….
Authors and Affiliations: Carla Pereira1,2,3, Ji-Hyeon Park4, Sofia Campelos1,5, Irene Gullo1,6,7, Carolina Lemos1,8,9, Leslie Solorzano10, Diana Martins1,2,11, Gilza Gonçalves2, Dina Leitão6,7, Hyuk-Joon Lee4,12,13, Seong-Ho Kong4,13, Ana André1,2, Clara Borges14, Daniela Almeida14, Carolina Wälbhy10, Raquel Almeida1,2,7,15, Woo Ho Kim16, Fátima Carneiro1,2,6,7, Han-Kwang Yang4,12,13, Gabriela M. Almeida1,2,7, Carla Oliveira1,2,7 1 i3S—Instituto de Investigação e Inovação em Saúde,…
Authors and affiliations: Sandra M Rocha 1, Inês Sousa 1,2, Inês M Gomes 1, Patrícia Arinto 1, Pedro Costa-Pinheiro 3, Eduarda Coutinho 1, Cecília R Santos 1, Carmen Jerónimo 3,4, Manuel C Lemos 1,5, Luís A Passarinha 1,6,7,8, Sílvia Socorro 1, Cláudio J Maia 1,5 1 CICS-UBI-Health Sciences Research Center, Universidade da Beira Interior, 6201-506…
The epidermal growth factor receptor (EGFR) is a protein leads to the activation of intracellular pathways that act directly on cell function, changes and survival. Cetuximab (CTX) is an anti-EGFR monoclonal antibody approved for the treatment of patients with head and neck squamous cell carcinoma (HNC) and metastatic colorectal cancer (mCRC). The response of patients…