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Work recently published in the “European Journal of Pharmacology” by Dr. Mélanie Barbosa, Dr. Ryan D. Kruschel et al., has demonstrated the potential of two isoquinolinequinone N-oxides (RK2 and RK3) as promising candidates for the next stages of drug development against multidrug resistant cancers, specifically linked to the overexpression of ABCB1. This work is the…

In recent years, the research group at UCIBIO – Laboratory of Toxicology, Faculty of Pharmacy, University of Porto – has focused on studying metabolic reprogramming in urological cancers to identify potential biomarkers with different clinical applications, including diagnosis, prognosis, and response to treatment. The most recent study aimed to characterise the metabolic signature of renal…

Authors and affiliations:Sara P. S. P. Moura 1,2, Silvia Marín 3,4, Ismael Rufino 5, Rita C. Guedes 5, Marta Cascante 3,4 and Jorge A. R. Salvador 1,2 1 Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal 2 Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal…

Authors and affiliations:Beatriz Medeiros-Fonseca1,2,3, Ana I. Faustino-Rocha1,2,4,5, Maria João Pires1,2,6, Maria João Neuparth7,8, Helena Vala1,2,9,10, Cármen Vasconcelos-Nóbrega1,2,9,10, Irene Gouvinhas1,2, Ana Novo Barros1,2, Maria Inês Dias11, Lillian Barros11, Margarida M. S. M. Bastos12,13, Lio Gonçalves14,15, Luís Félix1,2, Carlos Venâncio1,2,16,17, Rui Medeiros3,18,19,20,21, Rui Miguel Gil da Costa1,2,3,14,15,22, and Paula A. Oliveira1,2,6 1. Center for the Research and…

vCPP2319 interacts with metastatic breast cancer extracellular vesicles (EVs) and transposes a human blood-brain barrier model. Authors and affiliations:Filipa D. Oliveira (a), Marco Cavaco (a), Tiago N. Figueira (a), Patrícia Napoleão (a), Javier Valle (b), Vera Neves (a), David Andreu (b), Miguel A.R.B. Castanho (a) (a) Gulbenkian Institute for Molecular Medicine, Faculdade de Medicina da…

The poor prognosis of ovarian cancer, characterized by late diagnosis, high treatment resistance rates, and significant mortality, underscores the urgent need for improved prognostic and therapeutic strategies. In cancer patients, venous thromboembolism (VTE) is the second leading cause of death, with an even more pronounced impact in ovarian cancer due to the tumour’s biological characteristics,…

Authors and affiliations:João L. Pereira1,2,3, Liliana Arede1, Francisca Ferreira1,2,4, Andreia Matos1,5,6,7,8, Dulcineia Pereira1,2,9, Rita F. Santos1,10,11, Alexandre M. Carmo1,10, Maria J. Oliveira1,3,5, José C. Machado1,2,3, Delfim Duarte1,3,9, Nuno R. dos Santos1,2 1 i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. 2 IPATIMUP – Institute of Molecular Pathology and Immunology,…

Authors and Affiliations: Mariana Nunes 1,2 e Sara Ricardo 1,3,4,5 1 Instituto de Investigação e Inovação em Saúde (i3S) da Universidade do Porto, 4200-135 Porto, Portugal 2 Instituo de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal 3 Laboratório Associado i4HB, Instituto de Saúde e Bioeconomia, Instituto Universitário de Ciências da Saúde…

Authors and affiliations:Rita Carvalho 1,2,8, Liliana Santos 3,4,5, Inês Conde1,2,8, Ricardo Leitão3,4,5, Hugo R. S. Ferreira3,4,5, Célia Gomes 3,4,5, Ana Paula Silva3,4,5, Fernando Schmitt2,6,10, Carina Carvalho-Maia7, João Lobo7,8,9, Carmen Jerónimo7,8, Joana Paredes1,2,10, Ana Sofia Ribeiro1,2 1 Cancer Metastasis group, i3S – Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal. 2…

Authors and Affiliations: Mafalda Calheiros-Lobo 1,†,João P. N. Silva 1,†,Leonor Delgado 1,2,Bárbara Pinto 1,3,Luís Monteiro1,4,Carlos Lopes 1, Patrícia M. A. Silva 1,5,6,* and Hassan Bousbaa 1,* 1UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal 2Pathology…